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Shi-Lei XUE, Ph.D.
Biomechanics and Quantitative Biology Group (BQB)
Dr. Shi-Lei Xue obtained B.S. degree in Engineering from Nanjing University of Aeronautics and Astronautics. He earned Ph.D. degree in Solid Mechanics at Tsinghua University in 2018, with a research focus on the biomechanics of solid tumors. He joined Prof. Edouard Hannezo’s group at Institute of Science and Technology Austria as a postdoctoral research fellow, using methods from continuum mechanics and active matter physics to study living systems, as well as in the context of collaborations with developmental biologists.
In life processes such as embryonic development and tumorigenesis, force is crucial in sculpting tissue shape. Dr. Shi-Lei Xue focuses on multi-scale/multi-field coupling mechanics research on soft tissue development and formation: (1) multi-scale mechanical model linking the active forces of cells and large tissue deformation has been established, and unique morphological features of epithelia, such as phase transition and bistability, have been revealed; (2) mechano-chemo-biological coupling theory and computational method have been developed to demonstrate the mechanisms of tissue growth, vascular collapse and matrix swelling during tumor development.
“Biomechanics and quantitative biology” group is interested in the mechanical and physical principles behind sophisticated tissue morphologies across developmental stages. Main research topics include:
(1) Self-organization principles: how simple self-organizing pathways can sculpt complex tissue architecture?
(2) Coordination and coupling: how different cues such as mechanical forces and biochemical factors coordinate and couple together to form a tissue?
(3) Active mechanics theory: novel theory and computational methods are needed to capture the impact of cell-scale active force on tissue-scale deformation.
1. Qiutan Yang*, Shi-Lei Xue*, Chii Jou Chan, …, Edouard Hannezo, Prisca Liberali. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. Nature Cell Biology, 2021, 733–744. (Cover article) *Co-first authors
2. Marine Luciano*, Shi-Lei Xue*, Winnok H. De Vos, …, Edouard Hannezo, Sylvain Gabriele. Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation. Nature Physics, 2021, 1382–1390. *Co-first authors
3. Shi-Lei Xue, Si-Fan Yin, Bo Li, Xi-Qiao Feng. Biochemomechanical modeling of vascular collapse in growing tumors. Journal of the Mechanics and Physics of Solids, 2018, 121, 463–479.
4. Shi-Lei Xue, Shao-Zhen Lin, Bo Li, Xi-Qiao Feng. A nonlinear poroelastic theory of solid tumors with glycosaminoglycan swelling. Journal of Theoretical Biology, 2017, 433, 49–56.
5. Shi-Lei Xue, Bo Li, Xi-Qiao Feng, and Huajian Gao. A non-equilibrium thermodynamic model for tumor extracellular matrix with enzymatic degradation. Journal of the Mechanics and Physics of Solids, 2017, 104, 32–56.
6. Shi-Lei Xue, Bo Li, Xi-Qiao Feng, and Huajian Gao. Biochemomechanical poroelastic theory of avascular tumor growth. Journal of the Mechanics and Physics of Solids, 2016, 94, 409–432.
We are seeking enthusiastic Ph.D. students, postdoctoral scholars, assistant researchers and research assistants. Please feel free to contact firstname.lastname@example.org.