Ju-Sheng ZHENG, Ph.D.

School of Life Sciences

Laboratory of Human Nutrition and Epidemiology, Westlake University, China

CONTACT

Email: zhengjusheng@westlake.edu.cn

Website: https://www.wenutrition.cn/

Ju-Sheng ZHENG, Ph.D.

School of Life Sciences

Laboratory of Human Nutrition and Epidemiology, Westlake University, China

CONTACT

Email: zhengjusheng@westlake.edu.cn

Website: https://www.wenutrition.cn/

“Together with colleagues at Westlake University, I wish to witness a great start and prosperous future of the Westlake University at Hangzhou, China.”

Biography

Ju-Sheng got his PhD degree in nutrition at Zhejiang University, Hangzhou, China (2009-2014). Within his PhD program, he received one year’s training in the Nutrition and Genomics Lab at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in the USA (2012). He was also a Marie Skłodowska-Curie Individual Fellow supported by the European Commission and a postdoctoral researcher at the MRC Epidemiology Unit, University of Cambridge, UK (2015-2018).

Ju-Sheng joined the School of Life Sciences at Westlake University as a Principal Investigator and group leader in September 2018 and has been leading the Laboratory of Human Nutrition and Epidemiology at Westlake University. He is also an adjunct Professor at Qingdao University and Ningbo University, China.


Research

The major interest of Ju-Sheng’ current research is:

1)Use multi-omics techniques (including nutrition biomarkers, genomics, metabolomics, microbiome and proteomics) to investigate the etiology of aging-related diseases, especially metabolic diseases, and examine the role of diet/nutrition for healthy aging.

2)Precision nutrition: using novel study design (n-of-1 clinical trial) or cutting-edge wearable device (such as continuous glucose monitoring) to explore individual’ personalized response to diet and nutrition in the Chinese populations.

3)Explore the interplay among diet, genetics and gut microbiome on the host metabolism and offspring birth outcomes among pregnant women (especially gestational diabetes patients); and investigate the relationship of prenatal risk factors and early infant feeding practice with growth pattern and adiposity among Chinese children.


Selected Publications (*  corresponding author)

1. Shuai M, Zuo LS, Miao Z, Gou W, Xu F, Jiang Z, Ling CW, Fu Y, Xiong F, Chen YM*, Zheng JS*. Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiometabolic health. EBioMedicine 2021, 66:103284. doi: 10.1016/j.ebiom.2021.103284.

2. Gou W, Ling CW, He Y, Jiang Z, Fu Y, Xu F, Miao Z, Sun TY, Lin JS, Zhu HL, Zhou H, Chen YM*, Zheng JS*. Interpretable machine learning framework reveals robust gut microbiome features associated with type 2 diabetes. Diabetes Care 2021, 44(2):358-366. doi: 10.2337/dc20-1536.

3. Zheng JS, Luan J,Sofianopoulou E, Imamura F, Stewart ID, Day FR, Pietzner M, Wheeler E, Lotta LA, Gundersen TE, Amiano P, Ardanaz E, Chirlaque MD, Fagherazzi G, Franks PW,  Kaaks R, Laouali N, Mancini FR, Nilsson PM, N. Charlotte Onland-Moret C, Olsen A, Overvad K, Panico S, Palli D, Ricceri F, Rolandsson O, Spijkerman AMW, María-José Sánchez, Schulze MB , Sala N, Sieri S, Tjønneland A, Tumino R, van der Schouw YT, Weiderpass E, Riboli E, Danesh J, Butterworth AS, Sharp SJ, Langenberg C, Forouhi NG*, Wareham NJ*, Plasma vitamin C and type 2 diabetes: genome-wide association study and Mendelian randomization analysis in European populations. Diabetes Care 2021, 44(1):98-106. doi: 10.2337/dc20-1328.

4. Jiang Z, Sun TY, He Y, Gou W, Zuo LS, Fu Y, Miao Z, Shuai M, Xu F, Xiao C, Liang Y, Wang J, Xu Y, Jing LP, Ling W, Zhou H*, Chen YM*, Zheng JS*. Dietary fruit and vegetable intake, gut microbiota, and type 2 diabetes: results from two large human cohort studies. BMC Med. 2020, 18(1):371. doi: 10.1186/s12916-020-01842-0.

5. Miao Z, Lin JS, Mao Y, Chen GD, Zeng FF, Dong HL, Jiang ZL, Wang JL, Xiao CM, Shuai M, Gou W, Fu Y, Imamura F, Chen YM*, Zheng JS*. Erythrocyte n-6 polyunsaturated fatty acids, gut microbiota and incident type 2 diabetes: a prospective cohort study. Diabetes Care 2020, 43(10):2435-43.

6. Xu F, Fu Y, Sun TY, Jiang Z, Miao Z, Shuai M, Gou W, Ling CW, Yang J, Wang J*, Chen YM*, Zheng JS* The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases.Microbiome 2020, 8(1):145.

7. Fu Y, Gou W, Hu W, Mao Y, Tian Y, Liang X, Guan Y, Huang T, Li K, Guo X, Liu H*, Li D*, Zheng JS*. Integration of an interpretable machine-learning algorithm to identify early life risk factors of childhood obesity among preterm infants: a prospective birth cohort. BMC Med 2020, 18(1):184.

8. Zheng JS*, Luan J, Sofianopoulou E, Sharp SJ, Day FR, Imamura F, Thomas E, Lotta LA, Sluijs I, Stewart ID, Shah RL, van der Schouw YT, Wheeler E, Ardanaz E, Boeing H, Dorronsoro M, Dahm CC, Dimou N, El-Fatouhi D, Franks PW, Fagherazzi G, Grioni S, Huerta JM, Heath AK, Hansen L, Jenab M, Jakszyn P, Kaaks R, Kühn T, Kay-Tee Khaw, Laouali N, Masala G, Nilsson PM, Overvad K, Olsen A, Panico S, Quirós JR, Rolandsson O, Rodríguez-Barranco M, Sacerdote C, Spijkerman AMW, Tong TYN, Tumino R, Tsilidis KK, Danesh J, Riboli E, Butterworth AS, Langenberg C, Forouhi NG*, Wareham NJ*. The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis. PLoS Med2020, 17(10): e1003394. 

9. Zheng JS, Sharp SJ, Imamura F,  Rajiv C, Thomas GE, Marinka S, Sluijs I, van der Schouw YT, Agudo A, Aune D, Barricarte A, Boeing H, Chirlaque MD, Dorronsoro M, Freisling H, Fatoui DE, Franks PW, Fagherazzi G, Grioni S, Gunter MJ, Kyrø C, Katzke V, Kühn T, Khaw KT, Laouali N, Masala G, Nilsson PM, Overvad K, Panico S, Papier K, Quirós JR, Rolandsson O, Redondo-Sánchez D, Ricceri F, Schulze MB, Spijkerman AMW, Tjønneland A, Tong TYN, Tumino R, Weiderpass E, Danesh J, Butterworth AS, Riboli E, Forouhi NG, Wareham NJ. Association of plasma biomarkers of fruit and vegetable intake with incident type 2 diabetes: The EPIC-InterAct case-cohort study in eight European countries. BMJ 2020;370:m2194.

10. Zheng JS*, Chen J, Wang L, Yang H, Fang L, Yu Y, Yuan L, Feng J, Li K, Tang J, Lin M, Lai CQ, Li D*. Replication of a Gene-Diet Interaction at CD36, NOS3 and PPARG in Response to Omega-3 Fatty Acid Supplements on Blood Lipids: A Double-Blind Randomized Controlled Trial. EBioMedicine 2018, 31:150-156.


Full list of publications:

PubMed: https://www.ncbi.nlm.nih.gov/pubmed/?term=ju-sheng+zheng+or+jusheng+zheng

Lab website: https://www.wenutrition.cn/


Contact Information

E-mailzhengjusheng@westlake.edu.cn

Tel: +86-0571-86915303

Several postdoc positions are available at the Zheng lab for researchers globally.