Jie-Min JIA, Ph.D.

School of Life Sciences

Laboratory of Neurovascular Biology

CONTACT

Email: jiajiemin@westlake.edu.cn

Website:

Jie-Min JIA, Ph.D.

School of Life Sciences

Laboratory of Neurovascular Biology

CONTACT

Email: jiajiemin@westlake.edu.cn

Website:

"Completely believing in a book is worse than reading no book. I sincerely hope WIAS could be the place where people can have independent and critical thinking, where people can create authority and challenge the authority at spirally developing pace, where people can get the science close to truth as much as possible."


Biography

Dr.  Jie-Min Jia is an assistant professor in Westlake University at Hangzhou. She  received her Bachelor's Degree from Zhejiang Normal University in 2002 and Ph.D.  degree in Neurobiology at Institute of Neuroscience in Chinese Academy of  Sciences in 2008. Following a five-year postdoctoral research period at National  Institutes of Health, she joined UTSW as an assistant instructor in 2014. In  2017, she joined Westlake University as an independent principle investigator.  Dr. Jia received Di-Ao Award in 2009. 

 

Research

Dr. Jie-Min Jia's research provided important mechanisms  for neural circuitry homeostasis, elucidated spine pathology for schizophrenia  and created a novel focal ischemia animal model that is compatible with  real-time live imaging and suitable for newly born mice. She is one of the most  pioneers who utilize two-photon microscopy to study neurovascular unit in  stroke. Her state-of-art skill uncovered a new vascular pathology in stroke and  advanced the mechanistic understanding of neurovascular unit damage and repair  under stroke. Dr. Jia opened a new way to study neonatal stroke  pathology by combining genetics and  live-imaging technology. Dr. Jia received Di-AO prize from Chinese Academy of  Sciences and Director prize from Institute of Neuroscience, Shanghai. She has  been frequently invited to give a talk about her research by many pioneer  research agencies, such as Scientific committee of National Institute of Mental  Health at National Institutes of Health.

 

Representative  Publications

1. Jia JM, Chowdary PD, Gao X, Ci  B, Li W, Mulgaonkar A, Plautz EJ, Hassan G, Kumar A, Stowe AM, Yang SH, Zhou W,  Sun X, Cui B & Ge WP (2017) Control of Cerebral Ischemia with Magnetic  Nanoparticles. Nature Methods 14(2): 160-166.Nature  Methods 14(2): 160-166.

2. Jia JM, Hu Z, Nordman J, Li Z  (2014) The Schizophrenia Susceptibility Gene Dysbindin Regulates Dendritic Spine  Dynamics. Journal of Neuroscience 34 (41):  13725-13736.

3. Han MH, Jiao S, Jia  JM, Chen Y, Chen C, Gucek  M, Markey S, Li Z (2013) The Novel Caspase-3 Substrate Gap 43 Is Involved in  AMPA Receptor Endocytosis and Long-Term Depression. Molecular and  Cellular Proteomics 12 (12): 3719-3731.

4. Jia JM, Zhao J, Hu Z, Linberg D, Li Z  (2013). Age-Dependent Regulation of Synaptic Connections by Dopamine D2  Receptors. Nature Neuroscience 16 (11):  1627-1636.

5. Jia JM, Arnheiter H, Li Z  (2010) Schizophrenia Susceptibility Gene DISC1 Regulates Dendritic Spines  through Kalirin-7 and Rac1. Cell Science Review 6 (4):  13-18.

6. Li Z, Jo J, Jia JM, Lo SC, Whitcomb  DJ, Jiao S, Cho K, Sheng M (2010) Caspase-3 Activation via Mitochondria Is  Required for Long-Term Depression and AMPA Receptor  Internalization. Cell 141 (5): 859-871.

7. Chen M, Chen Q, Cheng XW, Lu TJ, Liu HX, Jia JM, Zhang C, Xu L, Xiong ZQ  (2009) Zn2+ Mediates Ischemia-Induced Impairment of The Ubiquitin-Proteasome System in The Rat Hippocampus. Journal of  Neurochemistry 111 (5): 1094-1103.

8. Jia JM, Chen Q, Zhou Y, Miao  S, Zheng J, Zhang C, Xiong ZQ (2008) Brain-Derived Neurotrophic  Factor-Tropomyosin-Related Kinase B Signaling Contributes to Activity-Dependent Changes in Synaptic Proteins. Journal of Biological  Chemistry 283 (30): 21242-50.