Huaizong SHEN, Ph.D.

School of Life Sciences

The Laboratory of Structural Biology of Membrane Proteins

CONTACT

Email: shenhuaizong@westlake.edu.cn

Website:

Huaizong SHEN, Ph.D.

School of Life Sciences

The Laboratory of Structural Biology of Membrane Proteins

CONTACT

Email: shenhuaizong@westlake.edu.cn

Website:

Biography

Dr. Huaizong Shen received his Bachelor of Science degree from the School of Life  Sciences, Shandong University in 2012, and his Ph.D. degree in Biology from  Tsinghua University in 2017. After that, he continued his research in Tsinghua  University as a postdoc during which period he was awarded the Outstanding  Scholar Award from the Beijing Advanced Innovation Center for Structural  Biology. Up till now, Dr. Shen has published a series of seminal research papers  in Science and  other high-profile  journals.

 

Research

Dr. Huaizong Shen has been working on the structural elucidation of eukaryotic  voltage-gated sodium channels (Nav channels). During  his Ph.D. and postdoc study, Dr. Huaizong Shen, together with other colleagues,  determined the first structure of a eukaryotic voltage-gated sodium channel,  NavPaS,  the first structure of Nav channels  bound with infamous neurotoxins, the first structure of human  Nav channel  and also the structure of human Nav1.7  which is directly associated with human pain sensation.

Dr.  Shen’s lab will focus on mechanism investigation of critical membrane proteins  such as channels and receptors with structural  and biochemical methods.

Subjects: Biochemistry;  Structural biology

 

Representative  Publications

1. Tian Li*, Kun Wu*, Zhenlei Yue*, Yifei Wang, Fan Zhang, Huaizong Shen# (2020). Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs. Molecular Cell. (*co-first authors, #correspondence author,下同)

2. Huaizong  Shen*, Dongliang  Liu*, Kun  Wu, Jianlin Lei, Nieng Yan (2019). Structures of human Nav1.7  channel in complex with auxiliary subunits and animal toxins. Science, eaaw2493. (* equal  contribution)

3. Xiaojing  Pan*,  Zhangqiang Li*,  Qiang Zhou*, Huaizong  Shen*,  Kun Wu*,  Xiaoshuang Huang, Jiaofeng Chen, Juanrong Zhang, Xuechen Zhu, Jianlin Lei, Wei  Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan (2018). Structure of the human  voltage-gated sodium channel Nav1.  4 in complex with β1. Science,  eaau2486. (* equal  contribution)

4. Huaizong Shen*, Zhangqiang Li*, Yan Jiang*, Xiaojing Pan*, Jianping Wu,  Ben Cristofori-Armstrong, Jennifer J. Smith, Yanni K. Y. Chin, Jianlin Lei,  Qiang Zhou, Glenn F. King, Nieng Yan (2018). Structural basis for the modulation  of voltage-gated sodium channels by animal toxins. Science,  eaau2596. (* equal  contribution)

5. Huaizong  Shen*, Qiang Zhou*,  Xiaojing Pan*, Zhangqiang Li*, Jianping Wu*, Nieng Yan (2017). Structure of a  eukaryotic voltage-gated sodium channel at near-atomic  resolution. Science, 355(6328),  eaal4326. (* equal  contribution)

6. Wei  Peng*, Huaizong  Shen*, Jianping  Wu*, Wenting Guo, Xiaojing Pan, Ruiwu Wang, S.R.Wayne Chen, Nieng Yan (2016).  Structural basis for the gating mechanism of the type 2 ryanodine receptor  RyR2. Science, 354(6310),  aah5324. (* equal  contribution)

7. Xiaojing  Pan*,  Zhangqiang Li*,  Xiaoshuang Huang*, Gaoxingyu  Huang*, Shuai  Gao, Huaizong  Shen, Lei  Liu, Jianlin Lei, Nieng Yan (2019). Molecular basis for pore blockade  of human Na+ channel  Nav1.2 by  the μ-conotoxin KIIIA. Science,  eaaw2999. (* equal  contribution)

8. Zhen Yan*,  Qiang Zhou*, Lin Wang*, Jianping Wu*, Yanyu Zhao, Gaoxingyu Huang, Wei  Peng, Huaizong  Shen, Jianlin Lei,  Nieng Yan (2017). Structure of the Nav1.4-β1 Complex  from Electric Eel. Cell.  170(3), 470-482.  e11. (* equal  contribution)


Positions Opening


Postdoctoral Associate/Fellow

Multiple postdoc positions are available in the lab. We are seeking sharp, experienced, creative and independent scientists who have excellent molecular or structural biology skills. Strong publication record in peer-reviewed journals and outstanding clarity of thought in communications are preferred. Internationally competitive salary and benefits (including social insurance, medical insurance, etc.) are provided. 

Research Assistant

Multiple research assistant positions are available in the lab. Expertise in molecular or structural biology is preferred. Internationally competitive salary and benefits  (including social insurance, medical insurance, etc.) are provided.