Search websites, locations, and people
Huaizong SHEN, Ph.D.
School of Life Sciences
The Laboratory of Structural Biology of Membrane Proteins
Dr. Huaizong Shen received his Bachelor of Science degree from the School of Life Sciences, Shandong University in 2012, and his Ph.D. degree in Biology from Tsinghua University in 2017. After that, he continued his research in Tsinghua University as a postdoc during which period he was awarded the Outstanding Scholar Award from the Beijing Advanced Innovation Center for Structural Biology. Up till now, Dr. Shen has published a series of seminal research papers in Science and other high-profile journals.
Dr. Huaizong Shen has been working on the structural elucidation of eukaryotic voltage-gated sodium channels (Nav channels). During his Ph.D. and postdoc study, Dr. Huaizong Shen, together with other colleagues, determined the first structure of a eukaryotic voltage-gated sodium channel, NavPaS, the first structure of Nav channels bound with infamous neurotoxins, the first structure of human Nav channel and also the structure of human Nav1.7 which is directly associated with human pain sensation.
Dr. Shen’s lab will focus on mechanism investigation of critical membrane proteins such as channels and receptors with structural and biochemical methods.
Subjects: Biochemistry; Structural biology
1. Tian Li*, Kun Wu*, Zhenlei Yue*, Yifei Wang, Fan Zhang, Huaizong Shen# (2020). Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs. Molecular Cell. (*co-first authors, #correspondence author,下同)
2. Huaizong Shen*, Dongliang Liu*, Kun Wu, Jianlin Lei, Nieng Yan (2019). Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins. Science, eaaw2493. (* equal contribution)
3. Xiaojing Pan*, Zhangqiang Li*, Qiang Zhou*, Huaizong Shen*, Kun Wu*, Xiaoshuang Huang, Jiaofeng Chen, Juanrong Zhang, Xuechen Zhu, Jianlin Lei, Wei Xiong, Haipeng Gong, Bailong Xiao, Nieng Yan (2018). Structure of the human voltage-gated sodium channel Nav1. 4 in complex with β1. Science, eaau2486. (* equal contribution)
4. Huaizong Shen*, Zhangqiang Li*, Yan Jiang*, Xiaojing Pan*, Jianping Wu, Ben Cristofori-Armstrong, Jennifer J. Smith, Yanni K. Y. Chin, Jianlin Lei, Qiang Zhou, Glenn F. King, Nieng Yan (2018). Structural basis for the modulation of voltage-gated sodium channels by animal toxins. Science, eaau2596. (* equal contribution)
5. Huaizong Shen*, Qiang Zhou*, Xiaojing Pan*, Zhangqiang Li*, Jianping Wu*, Nieng Yan (2017). Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science, 355(6328), eaal4326. (* equal contribution)
6. Wei Peng*, Huaizong Shen*, Jianping Wu*, Wenting Guo, Xiaojing Pan, Ruiwu Wang, S.R.Wayne Chen, Nieng Yan (2016). Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science, 354(6310), aah5324. (* equal contribution)
7. Xiaojing Pan*, Zhangqiang Li*, Xiaoshuang Huang*, Gaoxingyu Huang*, Shuai Gao, Huaizong Shen, Lei Liu, Jianlin Lei, Nieng Yan (2019). Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA. Science, eaaw2999. (* equal contribution)
8. Zhen Yan*, Qiang Zhou*, Lin Wang*, Jianping Wu*, Yanyu Zhao, Gaoxingyu Huang, Wei Peng, Huaizong Shen, Jianlin Lei, Nieng Yan (2017). Structure of the Nav1.4-β1 Complex from Electric Eel. Cell. 170(3), 470-482. e11. (* equal contribution)
Multiple postdoc positions are available in the lab. We are seeking sharp, experienced, creative and independent scientists who have excellent molecular or structural biology skills. Strong publication record in peer-reviewed journals and outstanding clarity of thought in communications are preferred. Internationally competitive salary and benefits (including social insurance, medical insurance, etc.) are provided.
Multiple research assistant positions are available in the lab. Expertise in molecular or structural biology is preferred. Internationally competitive salary and benefits (including social insurance, medical insurance, etc.) are provided.