Jianping WU, Ph.D.

School of Life Sciences

Biological Structure Laboratory

CONTACT

Email: wujianping@westlake.edu.cn

Website:

Jianping WU, Ph.D.

School of Life Sciences

Biological Structure Laboratory

CONTACT

Email: wujianping@westlake.edu.cn

Website:

Biography

Dr. Wu obtained his bachelor’s degree from Tsinghua University in 2012 and received his PhD degree in Structural biology from Tsinghua University in 2017. He then worked as a postdoc at Princeton University. His research was focused on molecular mechanism of membrane proteins including ion channels and transporters. His work has been published in Cell, Nature, Science etc. Dr. Wu has received the Outstanding Ph.D. Student Award (Tsinghua University and Beijing, 2017), Academic Excellence Award (Tsinghua University, 2017), and Wu Ray Prize (2017). Dr. Wu joined Westlake University as an Assistant Professor in 2019.


Research Interests

1.     Mechanistic understanding of the fertilization process;

2.     Structural investigations on disease-related proteins and protein complexes;

3.     Structure-based drug development.


Representative  Publications

1. Zhao, Y.*, Huang, G.*, Wu, J.*#, Wu, Q., Gao, S., Yan, Z., Lei, J., and Yan, N#. (2019). Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel. Cell in press (*co-first author   #co-corresponding author)

2. Wu, J.*, Yan, Z.*, Li, Z.*, Qian, X., Lu, S., Dong, M., Zhou, Q., and Yan, N. (2016). Structure of the voltage-gated calcium channel Cav1.1 at 3.6 A resolution. Nature 537, 191-196. (Ranked in the top ten Science and Technology Progress of China's universities in 2016)

3. Wu, J., Yan, N., and Yan, Z. (2017). Structure-Function Relationship of the Voltage-Gated Calcium Channel Cav1.1 Complex. Advances in experimental medicine and biology 981, 23-39.

4. Wu, J.*, Yan, Z.*, Li, Z., Yan, C., Lu, S., Dong, M., and Yan, N. (2015). Structure of the voltage-gated calcium channel Cav1.1 complex. Science 350, aad2395.

5. Peng, W.*, Shen, H.*, Wu, J.*, Guo, W., Pan, X., Wang, R., Chen, S.R., and Yan, N. (2016). Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science 354.

6. Yan, Z.*, Zhou, Q.*, Wang, L.*, Wu, J.*, Zhao, Y., Huang, G., Peng, W., Shen, H., Lei, J., and Yan, N. (2017). Structure of the Nav1.4-beta1 Complex from Electric Eel. Cell 170, 470-482 e411.

7. Shen, H.*, Zhou, Q.*, Pan, X.*, Li, Z.*, Wu, J.*, and Yan, N. (2017). Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science 355.

8. Bai, X.C.*, Yan, Z.*, Wu, J.*, Li, Z., and Yan, N. (2016). The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening. Cell research 26, 995-1006.

9. Gong, X.*, Qian, H.*, Zhou, X.*, Wu, J.*, Wan, T.*, Cao, P., Huang, W., Zhao, X., Wang, X., Wang, P., et al. (2016). Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell 165, 1467-1478.

10. Huang, X.*, Luan, B.*, Wu, J.*, and Shi, Y. (2016). An atomic structure of the human 26S proteasome. Nat Struct Mol Biol 23, 778-785.

11. Deng, D.*, Xu, C.*, Sun, P.*, Wu, J.*, Yan, C., Hu, M., and Yan, N. (2014). Crystal structure of the human glucose transporter GLUT1. Nature 510, 121-125. (Ranked in the top ten China Technology Progress in 2014)

12. Yan, Z., Bai, X.C., Yan, C., Wu, J., Li, Z., Xie, T., Peng, W., Yin, C.C., Li, X., Scheres, S.H., et al. (2015). Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature 517, 50-55.

link for the full listhttps://www.ncbi.nlm.nih.gov/myncbi/1TK2UfmBv5y5m/bibliography/public/

 

Contact Information

wujianping@westlake.edu.cn