Search websites, locations, and people
- Dean Hongtao YU
- Office of the Dean
- Core Lab
About School of Life Sciences
By building world-class research programs and centers, the School of Life Sciences strives to pursue questions fundamental to our understanding of biology and disease and to develop enabling technologies that benefit humanity and advance human health. The School is dedicated to cultivating future leaders in biomedical research, with an emphasis on multidisciplinary training in biology, chemistry, medicine, and engineering.
The School of Life Sciences plans to establish research programs in structural biology and biophysics, cell biology, biomedical engineering, stem cell research and therapy, neural and behavioral biology, bioinformatics, immunology and immunotherapy, epidemiology, metabolism, aging and degenerative diseases, cancer research, microbiology, and other related fields.
To facilitate research and training, the School of Life Sciences has launched the Advanced Biomedical Technology (ABT) Core Facility and the Animal Resource Center. The ABT Core Facility has established state-of-the-art platforms, including cryo-electron microscopy, mass spectrometry, flow cytometry, light microscopy, genomics, metabolism, bioinformatics, and high-throughout screening.
Office of the Dean
Dean Hongtao YU
Professor Hongtao YU received his B.S. in Chemistry from Peking University in 1990, and received his Ph.D. in Chemistry from Harvard University in 1995. He then completed his postdoctoral training at Harvard Medical School. Prof. Yu began his independent research career in 1999 as Assistant Professor in Department of Pharmacology at University of Texas Southwestern Medical Center. He was promoted to Associate Professor with tenure in 2004 and to Professor in 2008. From 2008-2019, he was appointed Howard Hughes Medical Institute (HHMI) Investigator. He was the holder of the Serena S. Simmons Distinguished Chair in Cancer Immunopharmacology before joining the faculty of Westlake University in December, 2019.
Prof. Yu studies the cellular mechanisms that govern chromosome inheritance and integrity, focusing on understanding the spindle checkpoint and sister-chromatid cohesion—cellular systems and processes that ensure all chromosomes are properly segregated during cell division. Defects in these processes lead to genomic instability and aneuploidy, which can cause birth defects, premature aging, and tumorigenesis. Using a multidisciplinary approach, his laboratory has contributed significantly to the molecular understanding of chromosome segregation and genome maintenance. His research has highlighted general principles in cell biology and revealed exquisite spatiotemporal control of opposing activities during cellular transitions.
Prof. Yu is a recipient of the Damon Runyon Scholar Award (1999), Burroughs Wellcome New Investigator Award in Pharmacological Sciences (2000), Packard Fellowship for Science and Engineering (2000), Leukemia and Lymphoma Society Scholar Award (2003), and W. M. Keck Distinguished Young Scholar Award (2003). He was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2012 and Board Member of Chinese Biological Investigator Society (CBIS) in 2018.
Office of the Dean
Kaina LI, Deputy Director
Wenyue YU, Administrative Assistant
（0571）86910287 email@example.com Research Affairs
Han DAI, Administrative Assistant
（0571）87928303 firstname.lastname@example.org Administrative Affairs
Xi CHENG, Administrative Assistant
（0571）87921963 email@example.com Human Resources
Lydia ZHU, Administrative Assistant
（0571）87025879 firstname.lastname@example.org Academic and Student Affairs
Chao Zhang, Administrative Assistant
（0571）86910287 email@example.com Finance
Computational Protein Design Lab
Somatic Stem Cell and Cancer Stem Cell Lab
Immune Regulation and Human Diseases
Laboratory of Protein Engineering and Protein Therapeutics
Principle Investigator, School of Life Sciences, Westlake University.
The Laboratory of Stem Cell Biology and Regenerative Medicine
Guomics Laboratory of Big Proteomic Data
Laboratory of Neuroimmunology
Laboratory Animal Resources Center
The Laboratory Animal Resources Center (LARC) provides various services for biomedical research, including: animal husbandry (mice & rats), rederivation, Tg or Cas9 mediated gene KO/KI/CKO by microinjection, speed expansion via IVF, strain rescue via IVF, cryopreservation and resuscitation, quality control of laboratory animals, consulting and support in the broad field of laboratory animal science, etc.
LARC has a 1,600-suqare-meter barrier system for animal breeding, holding and animal experiments. LARC interacts closely with the IACUC (Institutional Animal Care and Use Committee) to satisfy guidelines for the care and use of animals used in research. LARC was issued the License for the Use/Production of Laboratory Animals by Zhejiang Provincial Department of Science and Technology Agency. LARC has 8,200 square meters of space devoted to animal housing at Westlake University, Yungu.
LARC will be highly involved with research, teaching and training, and oversight the care and use of laboratory animals. The mission of LARC is to provide quality care for all animals used at Westlake University, to assist investigators in achieving their research goals, and to maintain the highest standards of humane care of animals used in research.
Biomedical Research Core Facilities
The Biomedical Research Core Facilities (BRCF) serve the ambitious multidisciplinary research at Westlake University. With a can-do attitude, the BRCF seeks to become an enabling mechanism by providing technical solutions that are beyond the capabilities of any individual laboratories, removing barriers to the implementation of complex and sophisticated scientific programs, thus allowing researchers to think big and tackle the most daunting challenges in biomedical research.
Closely aligned with the development of research programs at Westlake, the BRCF has installed a series of technological platforms, establishing a comprehensive research support system empowering diverse programs from dissection of biological macromolecules to studies of population health. As one of the earliest core facilities in operation at Westlake, the BRCF is currently consisted of eight facilities, including the CryoEM, Flow Cytometry, General Equipment & Autoclave Service, Genomics, High-throughput, Mass Spectrometry & Metabolomics, Microscopy, and Phenotypic Analysis Core Facilities. At present, the facilities will rely on recruitment of top professional teams and acquisition of state-of-the-art commercial instruments to support the rapid implementation of world-class basic research.
After the completion of the university campus at Yungu, the BRCF will further improve and strengthen its capabilities, delivering high-quality, high-efficiency, and professional services. The facilities will work closely with their counterparts at other colleges as well as research laboratories to actively participate in technological and scientific research, and in the meanwhile make the latest technological innovations available to Westlake researchers, which in turn will greatly facilitate the translation of new technologies. The BRCF will strive to build a world-class research support system, a platform for talent training, and an incubator for multidisciplinary collaborations.
Westlake University Supercomputer Center
Westlake University Supercomputer Center (WLSC) provides advanced computing and data analysis service for the cutting-edge scientific and engineering research in Westlake University. Founded in June 2019, WLSC now hosts one CPU cluster of 4080 CPU cores and 1.44PB parallel storage with 56Gbps inter-nodes connection. A GPU cluster equipped of NVidia Tesla V100 will be fully functional by Q1 of 2020. The computational resources in WLSC support multiple areas of research including biology, medical science, pharmaceutical sciences, physics, mathematics, chemistry, engineering, artificial intelligence and other related areas and are open to all Westlake University faculty, students, and staff. For more information, feel free to contact us at firstname.lastname@example.org.
Genomics and Bioinformatics Core Lab
Dr. Xi Wang obtained Bachelor degree from Tsinghua University and Ph.D. degree from Cornell University. Dr. Wang was mentored by Dr. Scott A. Armstrong and was trained in two top cancer research institutes - Memorial Sloan Kettering Cancer Center and Dana Farber Cancer Institute during her Ph.D. Her thesis focused on the genetic and epigenetic regulation in cancer. Dr. Wang has worked as a Scientist/Senior Scientist at Agios Pharmaceuticals and Merck Research Laboratories at Boston. Her work focused on oncology drug discovery, drug resistance and mechanisms of action using genomics and bioinformatics approaches.
Genomic technologies are powerful tools to explore gene expression, diseases associated DNA variants, epigenetic regulation, chromatin conformation, genetic dependency and many other fundamental biological questions. More recently, single cell sequencing has further improved our understanding of heterogeneous cell population and drug resistance at single cell level. The mission of this lab is to apply and develop genomics and bioinformatics methods to drive our understanding of biology and diseases. Our lab utilizes informatics and wet lab capabilities to interrogate biology and translational medicine questions. Key efforts of this lab are to
(1) Drive scientific discoveries through deep interdisciplinary collaboration;
(2) Develop and optimize novel genomic technologies and bioinformatic tools, including but not limited to, single cell multi-omics and novel functional genomics screening;
(3) Drug target identification