Xianjue MA, Ph.D.

School of Life Sciences

Signal Transduction and Cell Communication Lab

CONTACT

Email: maxianjue@westlake.edu.cn

Website:

Xianjue MA, Ph.D.

School of Life Sciences

Signal Transduction and Cell Communication Lab

CONTACT

Email: maxianjue@westlake.edu.cn

Website:

“Westlake University is where our dream begins, and a place we will never cease exploring the unknown.”


Biography

Xianjue Ma was born in 1987, and  received his Bachelor’s and Ph.D. degrees from Tongji University in 2009 and  2014, respectively. He then worked as a postdoctoral fellow at School of  Medicine of Johns Hopkins University (2014 - 2015) and Yale University (2015 -  2019). Dr. Ma has received a number of honors and awards including the Shanghai  Science and Technology Progress Prizes (First Class and Second Class), and  Pursuit of Excellence Award at Tongji University. Dr. Ma has been recruited as a  faculty in School of Life Sciences of Westlake University and will fully return  in June 2019.



Research

Dr.  Xianjue Ma has been working on genetics for more than a decade. By combining  genetics with developmental biology, cell biology, and biochemistry, we are  dedicated to dissecting the molecular mechanism of signaling transduction and  cell communication during tumorigenesis, using Drosophila (fruit fly) as a major model  organism. We have performed large scale genetic screens and successfully  identified numerous novel components of JNK and Hippo signaling, and revealed  their molecular mechanisms in regulating cell death, growth and tumorigenesis.  We also identified and named several novel tumor suppressors including  Fiery  Mountain and  Emei (not published yet). Currently, our  lab mainly focuses on the following directions:

1) Screen and characterization of novel  tumor suppressors or oncogenes.

2) Intra-and-inter cellular  communication during cancer progression.

3) Study the molecular mechanism of  tumor heterogeneity.

 


Representative  Publications

(* equal  contribution, # corresponding author)

1. Ma X*  #, Guo X*,  Richardson H, Xu T, Xue L#. POSH Regulates Hippo Signaling  Through Ubiquitin-Mediated Expanded Degradation. PNAS. 2018, 115(9):  2150-2155.

2. Ma  X*, Lu J*,  Dong Y, Li D, Malagon J, Xu T#. PP6 Disruption Synergizes with  Oncogenic Ras to Promote JNK-dependent Tumor Growth and Invasion.  Cell  Rep.  2017, 19(13):2657-2664.

3. Ma  X#, Wang H,  Jie J, Xu W, Sun Y, Li W, Zhang X#, Chen J#, Xue L#. Hippo Signaling Promotes  JNK-dependent Cell Migration. PNAS. 2017,  114(8):1934-1939.

4. Ma  X*, Huang J*,  Tian Y*, Chen Y, Yang Y, Zhang X#, Zhang F#, Xue L#. Myc Suppresses Tumor Invasion and  Cell Migration by inhibiting JNK Signaling. Oncogene. 2017,  36(22):3159-3167.

5. Ma  X#, Chen Y,  Zhang S, Xu W, Shao Y, Yang Y, Li W, Li M#, Xue L#. Rho1-Wnd Signaling Regulates Loss  of Cell Polarity-induced Cell Invasion in Drosophila. Oncogene. 2016,  35(7):846-55.

6. Ma  X#, Xu W,  Zhang D, Yang Y, Li W, Xue L#. Wnd Regulates JNK-Mediated Cell  Death in Drosophila. Cell Death  Dis.  2015, 6:e1737.

7. Ma  X*, Chen Y*,  Xu W, Wu N, Li M, Cao Y, Wu S, Xue L#. Impaired Hippo Signaling Promotes  Rho1-JNK Dependent Growth. PNAS. 2015,  112(4):1065-1070.

8. Ma  X*, Zheng H*,  Shao Y*, Li M, Li W#, Xue L#. Src42A Modulates JNK-Mediated  Tumor Migration and Cell Death in Drosophila. Cell Death  Dis.  2013, 4:e864.

9.  Ma  X*, Li W*, Yu  H, Li M, Xue L#, Xu T#. Bendless Modulates JNK-Mediated  Cell Death and Migration in Drosophila. Cell Death  Differ. 2014,  21(3):407-415.

10. Ma  X*, Yang L*,  Yang Y, Li M, Li W, Xue L#. dUev1a Modulates TNF-JNK Mediated  Tumor Progression and Cell Death in Drosophila. Dev Biol. 2013,  380(2):211-221.

11. Ma  X, Huang J,  Yang L, Yang Y, Li W, Xue L#. NOPO Modulates Egr-induced  JNK-Independent Cell Death in Drosophila. Cell Res. 2012,  22(2):425-431. 

 


Contact Information

Our lab is currently recruiting  multiple levels of researchers from all over the world. If you are interested,  please send your CV to email:maxianjue@westlake.edu.cn