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Xianjue MA, Ph.D.
School of Life Sciences
Signal Transduction and Cell Communication Lab
“Westlake University is where our dream begins, and a place we will never cease exploring the unknown.”
Xianjue Ma was born in 1987, and received his Bachelor’s and Ph.D. degrees from Tongji University in 2009 and 2014, respectively. He then worked as a postdoctoral fellow at School of Medicine of Johns Hopkins University (2014 - 2015) and Yale University (2015 - 2019). Dr. Ma has received a number of honors and awards including the Shanghai Science and Technology Progress Prizes (First Class and Second Class), and Pursuit of Excellence Award at Tongji University. Dr. Ma has been recruited as a faculty in School of Life Sciences of Westlake University and will fully return in June 2019.
Dr. Xianjue Ma has been working on genetics for more than a decade. By combining genetics with developmental biology, cell biology, and biochemistry, we are dedicated to dissecting the molecular mechanism of signaling transduction and cell communication during tumorigenesis, using Drosophila (fruit fly) as a major model organism. We have performed large scale genetic screens and successfully identified numerous novel components of JNK and Hippo signaling, and revealed their molecular mechanisms in regulating cell death, growth and tumorigenesis. We also identified and named several novel tumor suppressors including Fiery Mountain and Emei (not published yet). Currently, our lab mainly focuses on the following directions:
1) Screen and characterization of novel tumor suppressors or oncogenes.
2) Intra-and-inter cellular communication during cancer progression.
3) Study the molecular mechanism of tumor heterogeneity.
(* equal contribution, # corresponding author)
1. Ma X* #, Guo X*, Richardson H, Xu T, Xue L#. POSH Regulates Hippo Signaling Through Ubiquitin-Mediated Expanded Degradation. PNAS. 2018, 115(9): 2150-2155.
2. Ma X*, Lu J*, Dong Y, Li D, Malagon J, Xu T#. PP6 Disruption Synergizes with Oncogenic Ras to Promote JNK-dependent Tumor Growth and Invasion. Cell Rep. 2017, 19(13):2657-2664.
3. Ma X#, Wang H, Jie J, Xu W, Sun Y, Li W, Zhang X#, Chen J#, Xue L#. Hippo Signaling Promotes JNK-dependent Cell Migration. PNAS. 2017, 114(8):1934-1939.
4. Ma X*, Huang J*, Tian Y*, Chen Y, Yang Y, Zhang X#, Zhang F#, Xue L#. Myc Suppresses Tumor Invasion and Cell Migration by inhibiting JNK Signaling. Oncogene. 2017, 36(22):3159-3167.
5. Ma X#, Chen Y, Zhang S, Xu W, Shao Y, Yang Y, Li W, Li M#, Xue L#. Rho1-Wnd Signaling Regulates Loss of Cell Polarity-induced Cell Invasion in Drosophila. Oncogene. 2016, 35(7):846-55.
6. Ma X#, Xu W, Zhang D, Yang Y, Li W, Xue L#. Wnd Regulates JNK-Mediated Cell Death in Drosophila. Cell Death Dis. 2015, 6:e1737.
7. Ma X*, Chen Y*, Xu W, Wu N, Li M, Cao Y, Wu S, Xue L#. Impaired Hippo Signaling Promotes Rho1-JNK Dependent Growth. PNAS. 2015, 112(4):1065-1070.
8. Ma X*, Zheng H*, Shao Y*, Li M, Li W#, Xue L#. Src42A Modulates JNK-Mediated Tumor Migration and Cell Death in Drosophila. Cell Death Dis. 2013, 4:e864.
9. Ma X*, Li W*, Yu H, Li M, Xue L#, Xu T#. Bendless Modulates JNK-Mediated Cell Death and Migration in Drosophila. Cell Death Differ. 2014, 21(3):407-415.
10. Ma X*, Yang L*, Yang Y, Li M, Li W, Xue L#. dUev1a Modulates TNF-JNK Mediated Tumor Progression and Cell Death in Drosophila. Dev Biol. 2013, 380(2):211-221.
11. Ma X, Huang J, Yang L, Yang Y, Li W, Xue L#. NOPO Modulates Egr-induced JNK-Independent Cell Death in Drosophila. Cell Res. 2012, 22(2):425-431.
Our lab is currently recruiting multiple levels of researchers from all over the world. If you are interested, please send your CV to email：email@example.com