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Qi XIE, Ph.D.
School of Life Sciences
Cancer Stem Cell and Tumor Microenvironment lab
Dr. Qi Xie received his doctoral degree in Neurobiology at the Institute of Biophysics, Chinese Academy of Sciences in 2012. At the beginning of 2013, he joined Dr. Jeremy Rich’s lab at the Cleveland Clinic as a postdoctoral researcher. In August 2017, he moved to the University of California San Diego (UCSD) with Dr. Rich and was promoted as an Assistant Project Scientist. Dr. Qi Xie joined the West Lake University School of Life Sciences full-time in September 2019 as an assistant professor (independent PI), and continued to work on targeted therapies for cancer stem cells and brain tumors.
Cancer stem cell is a sub-population of cancer cells defined by sustained self-renewal, persistent proliferation, and tumor initiation capacity. Cancer stem cells play an essential role in tumor metastasis, recurrence, angiogenesis, chemotherapy and radiotherapy resistance, and immune evasion. Therefore, therapeutic strategies targeting cancer stem cells will bring new hope to the treatment of cancer.
Dr. Qi Xie’s research focuses on the epigenetic, transcriptional, post-translational, and metabolic regulation of cancer stem cells and their crosstalk with tumor microenvironment. He has published more than 20 papers including first author papers published in the top Journals such as Cell, Cancer Discovery, Immunity, Nature Neuroscience, Cell Research and Journal of Clinical Investigation. He has also been invited to write review and preview articles in Cell Stem Cell. He is currently a member of the American Cancer Society (AACR Member, since 2016), and is an independent reviewer for several journals including Clinical Cancer Research, Neuro-Oncology, and Cancer Letter.
We are particularly interested in the following directions:
1. Epigenetic and metabolic regulation of cancer stem cells
2. Crosstalk between tumor stem cells and tumor microenvironment
3. Improvement of tumor immunotherapy (CAR-T, CAR-NK, etc.)
1.Xie, Q. *, Wu, T. *, Gimple,C.R. *, Li, Z, ., Prager,C.B., Wu, Q., Yang, Y., Wang, P., Wang, Y., Gorkin, U.D., et al.(2018). N6-methyladenine DNA Modification in Glioblastoma. Cell 2018.10.006 (Co-first author) Highlighted by Nature Reviews Cancer, Cancer Discovery, Science Translational of Medicine and Nature Chemical Biology
2.Xie, Q., Wu, Q., Horbinski, C.M., Flavahan, W.A., Yang, K., Zhou, W., Dombrowski, S.M., Huang, Z., Fang, X., Shi, Y., et al. (2015). Mitochondrial control by DRP1 in brain tumor initiating cells. Nature neuroscience 18:501-5
3.Gimple, R.C., Kidwell, R.L., Kim, L.J.Y., Sun, T., Gromovsky, A.D., Wu, Q., Wolf, M., Lv, D., Bhargava, S., Jiang, L… Xie, Q#., Rich JN# (2019). Glioma Stem Cell-Specific Superenhancer Promotes Polyunsaturated Fatty-Acid Synthesis to Support EGFR Signaling. Cancer Discovery 9, 1248-1267 (Co-corresponding author)
4.Xie, Q., Wu, Q., Kim, L., Miller, T.E., Liau, B.B., Mack, S.C., Yang, K., Factor, D.C., Fang, X., Huang, Z., et al. (2016). RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. The Journal of clinical investigation 126, 2757-2772. Highlighted by JCI and Cancer Discovery
5.Tang, M*., Xie, Q*#., Gimple, R.C*., Zhong, Z., Tam, T., Tian, J., Kidwell, R.L., Wu, Q., Prager, B.C., Qiu, Z., et al. (2020). Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions. Cell Reserch (Co-first and Co-corresponding author）
6.Prager, B. C. *, Xie, Q. *, Bao, S. D. & Rich, J. N. (2019) Cancer Stem Cells: The Architects of the Tumor Ecosystem. Cell Stem Cell 24, 41-53, (Co-first author)
7.Xie, Q., Flavahan W.A., Bao S., Rich J. (2014) The Tailless Root of Glioma: Cancer Stem Cells. Cell Stem Cell 15(2):114-6
8.Dongrui Wang, Briana C Prager, Ryan C Gimple, Brenda Aguilar, Darya Alizadeh, Hongzhen Tang, Deguan Lv, Renate Starr, Alfonso Brito, Qiulian Wu…Qi Xie#, Christine E Brown#, Jeremy N Rich#(2021). CRISPR Screening of CAR T Cells and Cancer Stem Cells Reveals Critical Dependencies for Cell-Based Therapies. Cancer Discovery 11,1192-1211(Co-corresponding author)
9.Qiao Lu, Jia Liu, Shuai Zhao, Maria Florencia Gomez Castro, Maudry Laurent-Rolle, Jianbo Dong, Xiaojuan Ran, Payal Damani-Yokota, Hongzheng Tang, Triantafyllia Karakousi…Siyuan Ding#, Qi Xie#, Jun Wang#（2021）SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through ACE2-independent interactions via C-type lectin receptors and TTYH2. Immunity (accepted) (Co-corresponding author)
10.Miller, T.E., Liau, B.B., Wallace, L.C., Morton, A.R., Xie, Q., Dixit, D., Factor, D.C., Kim, L.J.Y., Morrow, J.J., Wu, Q., et al. (2017). Transcription elongation factors represent in vivo cancer dependencies in glioblastoma. Nature 547:355-359