Mingxuan WU, Ph.D.

School of Science

Protein Chemistry Laboratory

CONTACT

Email: wumingxuan@westlake.edu.cn

Website: https://mxwu.westlake.edu.cn/

Mingxuan WU, Ph.D.

School of Science

Protein Chemistry Laboratory

CONTACT

Email: wumingxuan@westlake.edu.cn

Website: https://mxwu.westlake.edu.cn/

Biography

Mingxuan grew up in Zhengzhou and went to the school of life science and biotechnology at Shanghai Jiao Tong University for a 6 year B.S.-M.S. program (2004-2010). His master thesis was advised by Dr. Huchen Zhou and Dr. Linquan Bai.

Next Mingxuan moved to the garden state in the U.S. and graduated from Princeton University with chemistry Ph.D. in 2015. He was advised by Dr. Dorothea Fiedler to study the cell signaling of diphosphoinositol polyphosphate using chemical tools.

Mingxuan then went to Maryland, where he joined the Phil Cole lab for postdoc training at Johns Hopkins University School of Medicine in 2015, and later moved to Harvard Medical School Brigham and Women’s Hospital in 2017. In the Cole lab, he used chemical tools to study the molecular mechanisms of the CoREST complex-chromatin interactions.

Mingxuan joined the school of science at Westlake University in fall 2019 as an assistant professor. His research interests include developments of novel chemical tools to understand how chromatin remodeling complexes regulate gene transcription via histone modifications.


Selected Publications

1. Y. Song, L. Dagil, L. Fairall, N. Robertson, M. Wu, T.J. Ragan, C. G. Savva, A. Saleh, N. Morone, M. B.A. Kunze, A. G. Jamieson, P. A. Cole, D. F. Hansen, and J. W.R. Schwabe. “Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex” Cell Rep., 2020, 30, 2699.

2. M. Wu, D. Hayward, J. H. Kalin, Y. Song, J. W.R. Schwabe and P. A. Cole. “Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex” eLife, 2018, 7:e37231.

3. J. H. Kalin, M. Wu, A. V. Gomez, Y. Song, J. Das, D. Hayward, N. Adejola, M. Wu, I. Panova, H. J. Chung, E. Kim, H. J. Roberts, J. M. Roberts, P. Prusevich, J. R. Jeliazkov, S. S. R. Burman, L. Fairall, C. Milano, A. Eroglu, C. M. Proby, A. T. Dinkova-Kostova, W. W. Hancock, J. J. Gray, J. E. Bradner, S. Valente, A. Mai, N. M. Anders, M. A. Rudek, Y. Hu, B. Ryu, J. W.R. Schwabe, A. Mattevi, R. M. Alani, P. A. Cole. “Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors.” Nat. Commun., 2018, 8:53.

4. M. Wu, L. S. Chong, D. H. Perlman, A. C. Resnick, D. Fiedler. “The inositol polyphosphates intersect with protein signaling and metabolic networks via two distinct mechanisms.” Proc. Natl. Acad. Sci. USA, 2016, 113, E6757.

5. M. Wu, L. S. Chong, S. Capolicchio, H. J. Jessen, A. Resnick, D. Fiedler. “Probing diphosphoinositol polyphosphate function with non-hydrolyzable analogs.” Angew. Chem. Int. Ed. 2014, 53, 7192-7197.

6. M. Wu, B. E. Dul, A. J. Trevisan, D. Fiedler. “Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers.” Chem. Sci. 2013, 4, 405-410.

7. C.-X. Liu, Q.-Q. Yin, H.-C. Zhou, Y.-L. Wu, J.-X. Pu, L. Xia, W. Liu, X. Huang, T. Jiang, M.-X. Wu, L.-C. He, Y.-X. Zhao, X.-L. Wang, W.-L. Xiao, H.-Z. Chen, Q. Zhao, A.-W. Zhou, L.-S. Wang, H.-D. Sun, G.-Q. Chen. “Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.” Nat. Chem. Biol. 2012, 8, 486-493.

8. M. Wu, Q. Meng, M. Ge, L. Bai, H. Zhou. “2,3,6-Trideoxy sugar nucleotides: synthesis and stability.” Tetrahedron Lett. 2011, 52, 5799-5801.