Haihua LU, Ph.D.

School of Science

The Laboratory of Natural Product Synthesis

CONTACT

Email: luhaihua@westlake.edu.cn

Website:

Haihua LU, Ph.D.

School of Science

The Laboratory of Natural Product Synthesis

CONTACT

Email: luhaihua@westlake.edu.cn

Website:

“Pursuing efficient complex molecule synthesis to appreciate the very beauty of nature, has been and will always be one of the most a(ttra)ctive research area of chemical science, and the focus of my future career. On this exciting path, new reaction methodologies will undoubtedly be explored and developed; while meeting brilliant collaborators to make discoveries to understand biological pathways and finally benefit people, will sure make this journey much more exhilarating.”


Biography

Haihua Lu was born in Suzhou in 1981. After earning his Ph.D. in 2010 with Professor Wen-Jing Xiao at the Central China Normal University (CCNU), investigating organocatalysis, he had an experience in pharmaceutical industry for one and a half years. He then continued his studies as a postdoctoral associate on natural product chemistry with Professor Markus Kalesse at the Leibniz Universität Hannover (LUH), supported by the Alexander von Humboldt foundation (AvH, 2012-2014), and later with Professor Ryan Shenvi at The Scripps Research Institute (TSRI, 2014-2016). He started his independent career as a professor in September 2016.


Research

Our lab is pursuing scalable complex molecule synthesis and drug development. During postdoctoral studies, the syntheses and biological studies of paleo-soraphens, (-)-jiadifenolide and (+)-diisocyanoadociane were accomplished. And, some of the results were published in Nature ChemistryJournal of American Chemical SocietyAngewandte Chemie International Edition etc. 


Representative Publications

1. M.-Y. Cao, B.-J. Ma, Z.-Q. Lao, H. Wang, J. Wang, J. Liu, K. Xing, Y.-H. Huang, K.-J. Gan, W. Gao, H. Wang, X. Hong, H.-H. Lu, Optically Active Flavaglines-Inspired Molecules by a Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation, J. Am. Chem. Soc. 2020, 142, DOI: 10.1021/jacs.0c05113.

2. H.-H. Lu#, S. Pronin#, Y. Antonova-Koch, S. Meister, E.A. Winzeler, R. A. Shenvi, Synthesis of (+)-7,20-Diisocyanoadociane and Liver Stage Antiplas-modial Activity of the ICT Class, J. Am. Chem. Soc. 2016, 138, 7268-7271.  (#equal contribution)

3. H.-H. Lu, M. Martinez, R. A. Shenvi, An Eight-step, Gram-scale Synthesis of (–)-Jiadifenolide, Nat. Chem. 2015, 7, 604-607.

Highlighted in Chemistry World, July 27 2015;

Highlighted by E. M. Carreira and M. Westph, Synfacts 2015, 11, 089;

# 1 most read article, June-July 2015.

4. H.-H. Lu, A. Raja, R. Franke, D. Landsberg, F. Sasse, M. Kalesse, Syntheses and Biological Evaluation of Paleo-Soraphens, Angew. Chem. Int. Ed. 2013, 52, 13549-13552.

5. H.-H. Lu, H. Liu, W. Wu, X.-F. Wang, L.-Q. Lu, W.-J. Xiao, Catalytic Asymmetric Intramolecular Hydroarylations of ω-Aryloxy- and Arylamino Tethered α,β-Unsaturated Aldehydes, Chem. Eur. J. 2009, 15, 2742-2746.

One of most accessed articles 2/2009–1/2010.

6. H.-H. Lu, X.-G. Meng, F.-G. Zhang, S.-W. Duan, W.-J. Xiao, Enantioselective Michael Reactions of β,β-Disubstituted Nitroalkenes: A New Approach to β2,2-Amino Acids with Hetero-Quaternary Stereocenters, Org. Lett. 2009, 11, 3946-3949

Highlighted by B. List and A. Lee, Synfacts 2009, 1164.