Biography

Dr. Chengchen Guo obtained B.S. degree in Chemistry from Nanjing University in 2011. After completion of the undergraduate, he earned Ph.D. degree in Chemistry from Arizona State University in Spring 2017 with a research focus on solid-state NMR spectroscopy and biopolymers. He then joined Prof. David L. Kaplan’s group at Tufts University as a postdoctoral fellow, where his research interest is to develop protein-based biofunctional medical devices for tissue engineering and regenerative medicine.

Research

The primary research focus is to develop functional biomaterials towards clinical translation with rational design and advanced processing. Some major research topics include:

1.     Protein-based bioresorbable materials for bone tissue repair and regeneration;

2.     Structure and properties of natural biopolymers (e.g. silk and collagen);

3.     Functional biopolymer-based nanocomposites and their biomedical applications.

Representative Publications

1. Chengchen Guo†, Chunmei Li†, Hiep V. Vu, Philip Hanna, Aron Lechtig, Yimin Qiu, Xuan Mu, Shengjie Ling, Ara Nazarian, Samuel Lin, David L. Kaplan, Thermoplastic Moulding of Regenerated Silk. Nat. Mater. 2020, 19, 102-108. († equal contribution)

2.Chunmei Li†, Chengchen Guo†, Vincent Fitzpatrick, Ahmed Ibrahim, Myrthe Zwierstra, Philip Hanna, Aron Lechtig, Ara Nazarian, Samuel Lin, and David Kaplan, Design of biodegradable implantable devices towards clinical translation. Nat. Rev. Mater. 2020, 5, 61-81. († equal contribution)

3. Ying Chen†, Chengchen Guo†, Eleana Manousiouthakis, Xiuli Wang, Dana M. Cairns, Terrence Roh, Chuang Du, David L. Kaplan, Bi-layered Tubular Microfiber Scaffolds as Functional Templates for Engineering Human Intestinal Smooth Muscle Tissue. Adv. Funct. Mater. 2020, 2000543. († equal contribution)

4. Chengchen Guo, Chunmei Li, Xuan Mu, David L. Kaplan, Engineering Silk Materials: From Natural Spinning to Artificial Processing. Appl. Phys. Rev. 2020, 7, 011313

5. Chengchen Guo, Chunmei Li, David L. Kaplan, Enzymatic Degradation of Bombyx mori Silk Materials: A Review. Biomacromolecules 2020, 21, 5, 1678-1686

6. Chengchen Guo*, Jin Zhang, Jacob S Jordan, Xungai Wang, Robert W Henning, Jeffery L Yarger, Structural Comparison of Various Silkworm Silks: An Insight into the Structure-Property Relationship. Biomacromolecules 2018, 19, 906. (* Co-corresponding author)

7. Chengchen Guo*, Jeffery L Yarger, Characterizing Gold Nanoparticles by NMR Spectroscopy. Magn. Reson. Chem. 2018, 11, 1074. (* Co-corresponding author)

8. Chengchen Guo*, Jacob S. Jordan, Jeffery L. Yarger, Gregory P. Holland, Highly Efficient Fumed Silica Nanoparticles for Peptide Bond Formation: Converting Alanine to Alanine Anhydride. ACS Appl. Mater. Interfaces 2017, 9, 17653. (* Co-corresponding author)

9. Chengchen Guo, Jin Zhang, Xungai Wang, Anh Tuan Nguyen, Xiang Yang Liu, David L Kaplan, Comparative Study of Strain-Dependent Structural Changes of Silkworm Silks: Insight into the Structural Origin of Strain-Stiffening. Small 2017, 13, 1702266.

10. Chengchen Guo, Gregory P. Holland, Jeffery L. Yarger, Lysine-capped Silica Nanoparticles: A solid-state NMR Spectroscopy Study. MRS Advance 2016, 31, 2261.

11. Chengchen Guo, Gregory P. Holland, Alanine Adsorption and Thermal Condensation at the Interface of Fumed Silica Nanoparticles: A Solid-state NMR Investigation. J. Phys. Chem. C 2015, 119, 25663.

12. Chengchen Guo, Genevieve N. Hall, John B. Addison, Jeffery L. Yarger, Gold Nanoparticle-doped Silk Film as Biocompatible SERS substrate. RSC Adv. 2015, 5, 1937.

13. Chengchen Guo, Gregory P. Holland, Investigating Lysine Adsorption on Fumed Silica Nanoparticles. J. Phys. Chem. C 2014, 118, 25792.