Dieter A. Wolf, M.D.

RNA and Disease Lab

CONTACT

Email: dawolf@westlake.edu.cn

Website:

DW.png
DW.png

Dieter A. Wolf, M.D.

RNA and Disease Lab

CONTACT

Email: dawolf@westlake.edu.cn

Website:

Biography

Dr. Wolf will join Westlake University as a Full Professor in 2023. He obtained his M.D. degree from the Ludwig-Maximilians University in Munich in 1995. After postdoctoral studies at Harvard and Stanford, he joined the Harvard School of Public Health as Assistant Professor in 1998, advancing to Associate Professor in 2003. In 2007, he became Full Professor at the Burnham Institute. In 2019, Dr. Wolf joined the MGZ Medical Genetics Center in Munich as resident in human genetics and medical head. Since 2021, he has held an adjunct research group leader position at the Technical University of Munich.

Research

The lab’s research has focusses on basic mechanisms of protein and energy homeostasis, their role in tumorigenesis, and their utility as cancer drug targets. Our work has concentrated on conserved pathways regulating protein homeostasis and associated stress response pathways. We have been pursuing these lines of investigation in human cell lines as well as in genetic models ranging from yeast to the mouse.

At Westlake University, our attention will shift to RNA-based mechanisms of disease. We plan to utilize multi-omics approaches and disease modeling in iPSCs to identify novel disease mechanisms with a focus on muscle and neurodegenerative disorders. We will also be pursuing approaches for the therapeutic targeting of RNA-based disease mechanisms.

Selected Publications

1. Jain S, HuC, Kluza J, Ke W, Bleilevels A, Tian G, Giurgiu M, Campos AR, Charbono A, Stickeler E, Maurer J, Holinski-Feder E, Vaisburg A, Bureik M, Luo G, Marchetti P, Cheng Y, Wolf DA. Targeting cancer metabolism through a ubiquinone uncompetitive inhibitor of mitochondrial complex I, (2022) Cell Chemical Biology, 29, 436-450.e15, 10.1016/j.chembiol.2021.11.002

2. Tian G, Hu Cheng, Yun Y, Yang W, Dubiel W, Cheng Y, Wolf DA. Dual roles of HSP70 chaperone HSPA1 in promoting quality control of nascent and newly synthesized proteins. (2021) EMBO J., e106183, 10.15252/embj.2020106183

3. Wang J, Dubiel D, Wu Y, Cheng Y, Wolf DA*, Dubiel W*.  CSN7B defines a variant COP9 signalosome complex with distinct function in DNA damage response. (2021) Cell Reports, 34: 108662, 10.1016/j.celrep.2020.108662 * Co-corresponding authors

4. Lin Y, Li F, Huang L, Polte C, Duan H, Fan J, Sun L, Xing X, Tian G, Cheng Y, Ignatova Z, Yang X, Wolf DA. eIF3 associates with 80S ribosomes to promote translation elongation, mitochondrial homeostasis, and muscle health. (2020) Molecular Cell 79, 1-13, 10.1016/j.molcel.2020.06.003

5. Shah M, Su D, Scheliga JS, Pluskal T, Boronat S, Shah M, Motamedchaboki K, Campos AR, Qi F, Yanagida M, Wolf DA. A transcript-specific eIF3 complex mediates global translational control of energy metabolism (2016), Cell Reports 16:1891-1902, 10.1016/j.celrep.2016.07.006

Contact Information

The Wolf lab has opening for postdoctoral fellows, graduate students, and research assistants. Please send your resume todawolf@westlake.edu.cn.