(*co-first author ^#co-corresponding author)

At Westlake University

1. Li, Z.*, Xu, Q.*, Zhong, J.*, Zhang, Y.*, Zhang, T.*, Ying, X.*, Lu, X., Li, X., Wan, L., Xue, J., Huang, J., Zhen, Y., Zhang, Z., Wu, J.#, Shen, E^#. (2025). Structural insights into RNA cleavage by PIWI Argonaute. Nature.

2. Wan, L.*, Ge, X.*, Xu, Q.*, Huang, G.*, Yang, T., Campbell, K.P., Yan, Z.^#, and Wu, J.^# (2024). Structure and assembly of the dystrophin glycoprotein complex. Nature

3. Li, Z.*, Li, Z.*, Zhang, Y., Zhou, L., Xu, Q., Li, L., Zeng, L., Xue, J., Niu, H., Zhong, J., Yu, Q., Li, D., Gui, M., Huang, Y., Tu, S., Zhang, Z., Song, C.^#, Wu, J.#, and Shen,E.^# (2024). Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing. Nat Struct Mol Biol. doi:10.1038/s41594-024-01287-6.

4. Yang, A.*, Liu, S.*, Zhang, Y.*, Chen, J., Fan, Y., Wang, F., Zou, Y., Feng, S., Wu, J.^#, and Hu, Q.^# (2024). Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation. Nat Struct Mol Biol. 10.1038/s41594-023-01183-5.

5. Zhou, L.*, Liu, H.*, Liu, S.*, Yang, X., Dong, Y., Pan, Y., Xiao, Z., Zheng, B., Sun, Y., Huang, P., Zhang, X., Hu, J., Sun, R., Feng, S., Zhu, Y., Liu, N.^#, Gui, M.^#, Wu, J.^#. (2023). Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Cell 186, 2897-2910 e2819.

6. Zhou, L., Liu, H., Zhao, Q., Wu, J.^# & Yan, Z.^# (2022). Architecture of the human NALCN channelosome. Cell Discov 8, 33.

7. Lin, S.*, Ke, M.*, Zhang, Y., Yan, Z., Wu, J. (2021). Structure of a mammalian sperm cation channel complex. Nature 595, 746-750.

Highlighted by News and Views in Nature:

Clapham, D., Hulse, R. (2021) Sperm CatSper ion channel swims into sharper focus. Nature 595, 654-655

8. Mou, L.*, Ke, M.*, Song, M., Shan, Y., Xiao, Q., Liu, Q., Li, J., Sun, K., Pu, L., Guo, L., Geng, J.^#, Wu, J.^#, Deng, D.^# (2020). Structural basis for gating mechanism of Pannexin 1 channel. Cell Res 30, 452-454.

9. Xie, J.*, Ke, M.*, Xu, L.*, Lin, S., Zhang, J., Yang, F.^#, Wu, J.^#, Yan, Z.^# (2020). Structure of the human sodium leak channel NALCN in complex with FAM155A. Nat Commun 11, 5831.

Before 2019

10. Zhao, Y.*, Huang, G.*, Wu, J.*^#, Wu, Q., Gao, S., Yan, Z., Lei, J., and Yan, N^#. (2019). Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel. Cell 177, 1495-1506 e1412.

11. Wu, J.*, Yan, Z.*, Li, Z.*, Qian, X., Lu, S., Dong, M., Zhou, Q., and Yan, N. (2016). Structure of the voltage-gated calcium channel Ca_v1.1 at 3.6 A resolution. Nature 537, 191-196. (Top ten Science and Technology Progress of Chinese Universities in 2016)

12. Wu, J., Yan, N., and Yan, Z. (2017). Structure-Function Relationship of the Voltage-Gated Calcium Channel Ca_v1.1 Complex. Advances in experimental medicine and biology 981, 23-39.

13. Wu, J.*, Yan, Z.*, Li, Z., Yan, C., Lu, S., Dong, M., and Yan, N. (2015). Structure of the voltage-gated calcium channel Ca_v1.1 complex. Science 350, aad2395.

14. Peng, W.*, Shen, H.*, Wu, J.*, Guo, W., Pan, X., Wang, R., Chen, S.R., and Yan, N. (2016). Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2. Science 354, aah5324.

15. Yan, Z.*, Zhou, Q.*, Wang, L.*, Wu, J.*, Zhao, Y., Huang, G., Peng, W., Shen, H., Lei, J., and Yan, N. (2017). Structure of the Na_v1.4-beta1 Complex from Electric Eel. Cell 170, 470-482 e411.

16. Shen, H.*, Zhou, Q.*, Pan, X.*, Li, Z.*, Wu, J.*, and Yan, N. (2017). Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution. Science 355, aal4326.

17. Gong, X.*, Qian, H.*, Zhou, X.*, Wu, J.*, Wan, T.*, Cao, P., Huang, W., Zhao, X., Wang, X., Wang, P., et al. (2016). Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection. Cell 165, 1467-1478.

18. Deng, D.*, Xu, C.*, Sun, P.*, Wu, J.*, Yan, C., Hu, M., and Yan, N. (2014). Crystal structure of the human glucose transporter GLUT1. Nature 510, 121-125. (Top ten China Technology Progress in 2014)