After 2019

1. Zhu, J.#, Guo, R.#, Hu, Q.* (2026). Control of the signaling of RAS proteins by modulating their palmitoylation. Cell Chemical Biology, 2026 Mar 17, doi: 10.1016/j.chembiol.2026.02.009.

2. Peng, H.#, Xu, Q.#, Zhang, T., Zhu, J., Pan, J., Guan, X., Feng, S., Wu, J.*, Hu, Q.* (2025). Molecular determinants for the association of human hormone-sensitive lipase with lipid droplets. Nature Communications, 16(1), 3497. (*co-corresponding author)

3. Zhou, F.#, Zhang, Y.#, Zhu, Y., Zhou, Q., Shi, Y., Hu, Q.* (2024). Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase. Science Advances, 10, eado4880. DOI:10.1126/sciadv.ado4880

4. Sun, Y., Zhou, R., Hu, J., Feng, S., Hu, Q.* (2024). Reversible control of kinase signaling through chemical-induced dephosphorylation. Communications Biology, 7(1), 1073.

5. Zhou, F.#, Zhang, Y.#, Zhu, Y., Zhou, Q., Shi, Y., Hu, Q.* (2024) Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC). eLife, 13:RP98885. https://doi.org/10.7554/eLife.98885.1

6. Zhang, L.#, Xie, X.#, Luo, H., Yu, H., Huang, J., Shi, P. Y.* & Hu, Q.* (2024). Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04. Cell Discovery, 10:40. (* co-corresponding author)

7. Yang, A.#, Liu, S.#, Zhang, Y.#, Chen, J., Fan, Y., Wang, F., Zou, Y., Feng, S., Wu, J.* & Hu, Q.* (2024). Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation. Nature Structural & Molecular Biology, 1-11. (* co-corresponding author)

8. Hou, N.#, Shuai, L.#, Zhang, L.#, Xie, X.#, Tang, K., Zhu, Y., ... Shi, P. Y.*, Bu, Z.*, Huang, J.* & Hu, Q.* (2023). Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro. ACS Cent. Sci., 9(2), 217-227. (* co-corresponding author)

9. Dai, S. A.#, Hu, Q.#, Gao, R.#, Blythe, E. E., Touhara, K. K., Peacock, H., ... & Shokat, K. M. (2022). State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides. Cell, 185(21), 3950-3965. (# co-first author)

10. Hou, N., Peng, C., Zhang, L., Zhu, Y., & Hu, Q. (2022). BRET-based self-cleaving biosensors for SARS-CoV-2 3CLpro Inhibitor Discovery. Microbiology Spectrum, e02559-21.

Before 2019

1. Hu, Q., Shokat, K.M. (2018). Disease-causing mutations in the G protein Gαs subvert the roles of GDP and GTP. Cell 173, 1254-1264.e11.

2. Li, Y.#, Zhou, M.#, Hu, Q.#, Bai, X.-C., Huang, W., Scheres, S.H.W., and Shi, Y. (2017). Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme. Proc Natl Acad Sci U S A 114, 1542–1547. (# co-first author)

3. Wang, J., Yan, C., Li, Y., Hirata, K., Yamamoto, M., Yan, N.*, and Hu, Q.* (2014). Crystal structure of a bacterial homologue of SWEET transporters. Cell Res 24, 1486-1489. (* co-corresponding author)

4. Hu, Q.#, Wu, D.#, Chen, W., Yan, Z., Yan, C., He, T., Liang, Q., and Shi, Y. (2014). Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome. Proc Natl Acad Sci U S A 111, 16254-16261. (# co-first author)

5. Hu, Q.#, Wu, D.#, Chen, W., Yan, Z., and Shi, Y. (2013). Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9. J Biol Chem 288, 15142-15147. (# co-first author)

6. Wu, D.#, Hu, Q.#, Yan, Z.#, Chen, W., Yan, C., Huang, X., Zhang, J., Yang, P., Deng, H., and Wang, J., et al. (2012). Structural basis of ultraviolet-B perception by UVR8. Nature 484, 214-219. (# co-first author)

7. Hu, Q., Nie, A., Welsh, K., Pinacho, C.F., Zhu, X., Li, Z., An, J., Reed, J.C., Zhang, L., and Huang, Z. (2011). Novel X-linked inhibitor of apoptosis protein inhibitors as probes of apoptosis in biology and medicine. Exp Biol Med (Maywood) 236, 247-251.