Cell lineages, defined as the division history of cells within an organism, are essential for understanding the mechanisms underlying development, aging, and disease. Lineage tracing aims to reconstruct the division history of cells in the body. In the field of single-cell lineage tracing, Dr. Wang has made several groundbreaking contributions, including:

1. Developing CoSpar, a computational tool that integrates cellular lineage and transcriptomics to accurately predict cell fate (2022, Nature Biotechnology, first and co-corresponding author).

2. Co-developing the next-generation lineage-tracing mouse model DARLIN, the single-cell multi-omics technology Camellia-seq, and uncovering epigenetic clonal memory in hematopoietic stem cells (2023, Cell, co-corresponding author).

3. Creating MethylTree, a non-invasive lineage-tracing tool based on DNA methylation mutations (2025, Nature Methods, corresponding author).

The lab currently focuses on advancing single-cell DNA methylation research and lineage-tracing technologies. One focus is developing high-throughput, cost-effective single-cell DNA methylation profiling methods, improving the reliability of lineage-tracing algorithms, and applying these innovations to various human tissues to conduct multi-omics lineage tracing. These efforts aim to address previously unresolved fundamental scientific questions. Another focus is leveraging machine learning to extract deeper insights from DNA methylation data, offering a fresh perspective on development and aging at the epigenetic level.

Our lab is deeply interdisciplinary, blending experimental and computational approaches. We welcome individuals with backgrounds in experimental biology, computational biology, physics, computer science, and related fields to join us. For more information, please visit our website: https://www.shouwenwang-lab.com/.