NEWS & EVENTS Event Calendars Event

Time & Date

4:00-5:30 PM, Tuesday, Apr. 6, 2021

Venue

Room 312, 3F, Building 3, Yunqi Campus

Host

Dr. Kai Lei, School of Life Science

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research

SLS Seminar Series | Transplantation of human cerebral organoids establish region-specific projections in the adult mouse brain

Time: 4:00-5:30 PM, Tuesday, Apr. 6, 2021

Venue: Room 312, 3F,Building 3, Yunqi Campus

Host: Dr. Kai Lei, School of Life Science

Speaker:


Prof. Yan Liu

School of Pharmacy Nanjing Medical University

南京医科大学药学院特聘教授


Dr. Yan Liu is a professor from the Institute for stem cell and neural regenerative medicine, School of Pharmacy, Nanjing Medical University. She got her Ph.D degree from Fudan University, and worked as Postdoc in University of Wisconsin, USA and focused on the research on directed differentiation of human pluripotent stem cells and regenerative medicine for years. Dr Yan Liu’s laboratory is mainly focus on: 1. generation of region-specific brain organoids from human pluripotent stem cells; 2. cell therapy for neurological disease; 3. studying pathogenesis of neurological diseases by using patient-specific iPSCs. Dr. Yan Liu is currently heading the projects of the Chinese Academy of Sciences, the National Natural Science Fund for Excellent Young Scholars, and the National Key Research and Development Program, etc.


Abstract:

Human pluripotent stem cell-derived three-dimensional brain organoids have great potential for studying human neural development and modeling human neurological disorders. Although numerous in vitro studies had investigated many aspects of human brain organoids, the long axonal connection distances, protracted maturation and the proper function of grafted organoids should be observed precisely. Here, we modified the method of culture system and generated small human cerebral organoids. After transplantation of organoids into the medial prefrontal cortex of severe combined immune-deficiency mice, the human organoids survived and sent long projections to lateral hypothalamus. We use immunofluorescence, electrophysiological and retrograde tracing techniques to systematically investigate the morphology, projections across brain regions and function of the human neural graft. Furthermore, we observed the human brain organoids improved the behavior of mice. Our study showed the maturation and neural circuit formation of grafted human organoids, which might provide novel insights into the neurological transplantation studies.


Contact:

Wenyue Yu

yuwenyue@westlak.edu.cn


Time & Date

4:00-5:30 PM, Tuesday, Apr. 6, 2021

Venue

Room 312, 3F, Building 3, Yunqi Campus

Host

Dr. Kai Lei, School of Life Science

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research