NEWS & EVENTS Event Calendars Event

Time & Date

2:45-4:00 PM, Thursday, Apr. 22, 2021

Venue

Room 312, Building 3, Yunqi Campus

Host

Dr. Peilong Lu, PI of School of Life Sciences, Westlake University

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research

93rd Westlake Master Forum | Ting Zhu: Building Mirror-image Biology Systems

Time:2:45-4:00 PM, Thursday, Apr. 22, 2021

Venue: Room 312, Building 3, Yunqi Campus

Host: Dr. Peilong Lu, PI of School of Life Sciences, Westlake University




Speaker: Ting Zhu, Professor of School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University

Ting Zhu received his B.E. from the Department of Engineering Mechanics at Tsinghua University, M.S. from the Department of Mechanical Engineering at MIT, Ph.D. from the Harvard-MIT Division of Health Sciences and Technology, and postdoctoral training from the Department of Earth, Atmospheric and Planetary Sciences at MIT and Department of Molecular Biology at Massachusetts General Hospital. He joined the School of Life Sciences at Tsinghua University in 2011.

Title:

Building Mirror-image Biology Systems

Abstract:

The overwhelmingly homochiral nature of life has left a puzzle as to whether mirror-image biology systems based on a chirally inverted version of molecular machinery could also exist. We initially demonstrated that two processes in the central dogma of molecular biology, the replication of DNA and transcription from DNA into RNA, can be catalyzed by a chemically synthesized D-polymerase on an L-DNA template. Using designed mutants of the D-polymerases, we also realized mirror-image PCR, gene transcription, reverse transcription, as well as mirror-image DNA and RNA sequencing. Next, toward building a mirror-image ribosome, we enzymatically transcribed the full-length mirror-image 5S ribosomal RNA, which can assemble with synthetic mirror-image ribosomal proteins into stable ribonucleoprotein complexes. Furthermore, we realized protein translation without aminoacyl-tRNA synthetases and ribozyme-catalyzed mirror-image tRNA charging. Our work is a small step toward realizing the mirror-image central dogma, and ultimately, the creation of mirror-image life. It also highlights the potential to exploit mirror-image biomolecules as a new class of research and therapeutic tools.

Contact:

biguanying@westlake.edu.cn




Time & Date

2:45-4:00 PM, Thursday, Apr. 22, 2021

Venue

Room 312, Building 3, Yunqi Campus

Host

Dr. Peilong Lu, PI of School of Life Sciences, Westlake University

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research