NEWS & EVENTS Event Calendars Event

Time & Date

2:00-3:30 PM,Mon.,June 7,2021

Venue

Room 312, 3F, Building 3,  Yunqi Campus

Host

Dr. Tiannan Guo, School of Life Sciences

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research

SLS Special Seminar | Fan Liu: Developing structural interactomics and its application in cell biology

Time2:00-3:30 PM,Mon.,June 7,2021

Venue: Room 312, 3F, Building 3,  Yunqi Campus

Host:Dr. Tiannan Guo, School of Life Sciences



Speaker:

Dr. Fan Liu

Professor for Structural Interactomics, Charité - Universitätsmedizin Berlin


Prof. Dr. Fan Liu graduated from Fudan University in Shanghai with a B.Sc. in Biology. Afterwards she joined the lab of Prof. Dr. Mike Goshe at North Carolina State University and obtained her PhD in Biochemistry in 2013. Fan did her postdoc in the lab of Prof. Dr. Albert Heck (Utrecht, The Netherlands).

In 2017 Fan joined the Leibniz-Forschungsinstitut for Molecular Pharmacology (FMP) in Berlin as a group leader for Structural Interactomics and head of the proteomics research platform. In addition to her position at the FMP, Fan is jointly appointed as Professor for Structural Interactomics at Charité - Universitätsmedizin Berlin.


Abstract:

Proteins are involved in almost all cellular processes. They are organized through extensive networks of interactions, regulating the working mechanisms of the cell with high fidelity and precision. However, characterization of the protein interactome has been an extremely challenging task due to the lack of highly confident and efficient technology. To address this issue, we describe a leap forward in cross-linking mass spectrometry demonstrating a new integrated workflow that robustly identifies thousands of protein-protein interactions (tens of thousands of cross-links) from (sub)proteome samples. We applied this novel XL-MS strategy to several highly complex samples, including the intact virion, the mitochondrion and the neuronal synapse. The XL-MS-based method not only reveals protein partnerships systematically but also provides critical insights into the architecture and spatial organization of the complex proteome in various biological systems.


Contact:

Wenyue Yu: yuwenyue@westlake.edu.cn

School of Life Sciences


Time & Date

2:00-3:30 PM,Mon.,June 7,2021

Venue

Room 312, 3F, Building 3,  Yunqi Campus

Host

Dr. Tiannan Guo, School of Life Sciences

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research