NEWS & EVENTS Event Calendars Event

Time & Date

16:00-17:30, Thursday, June 17th, 2021

Venue

Lecture Hall, 1F, Building 5, Yunqi Campus, Westlake University

Host

Dr. Haihua Lu, PI of School of Science, Westlake University

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research

Chemistry Colloquium | Shuli You: Catalytic Asymmetric Dearomatization (CADA) Reactions

Time16:00-17:30, Thursday, June 17th, 2021

Host: Dr. Haihua Lu, PI of School of Science, Westlake University

Venue: Lecture Hall, 1F, Building 5, Yunqi Campus, Westlake University


Prof. Shu-Li You,

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, CAS, 345 Lingling Lu, Shanghai, China

E-mail: slyou@mail.sioc.ac.cn


Speaker

Prof. Shu-Li You received his BSc in chemistry from Nankai University in 1996. He obtained his PhD from the Shanghai Institute of Organic Chemistry (SIOC) in 2001 under the supervision of Prof. Li-Xin Dai before doing postdoctoral studies with Prof. Jeffery W. Kelly at The Scripps Research Institute. From 2004, he worked at the Genomics Institute of the Novartis Research Foundation as a Principal Investigator before returning to SIOC in 2006. Since January 2017, He has been appointed as the Director of the State Key Laboratory of Organometallic Chemistry. His current research interests include asymmetric catalysis, synthetic methodology, natural product synthesis, as well as medicinal chemistry. Prof. Shu-Li You has published over 300 peer-reviewed papers and edited two books, and applied over 30 Chinese patents as a co-inventor. Dr. You’s papers have received total citations by others over 17000 and his h-index is 82 (until May 2021). He is the recipient of AstraZeneca Excellence in Chemistry Award (2011), RSC Merck Award (2015), Ho Leung Ho Lee Foundation Prize for Scientific and Technological Innovation (2016) and Novartis Chemistry Lectureship (2017/2018).

Abstract:

Dearomatization reactions are widely recognized as powerful methods for the synthesis of highly functionalized three-dimensional structures from simple planar aromatic compounds. Among those, catalytic asymmetric dearomatization (CADA) reactions are very attractive due to the abundance and ready availability of aromatic compounds and the direct access to enantiopure polycycles and spirocycles offered by them. That latter are frequently the key motifs in biologically active natural products and pharmaceuticals. However, due to the extra stability of “aromaticity” of the arenes, their dearomatization reactions with good enantioselective control has been a great challenge. In this talk, the application of TM-catalyzed allylic substitution reactions in dearomatization process will be reported. The dearomatization reactions of indoles, pyrroles, phenols, naphthols, and pyridines have been achieved, affording various highly functionalized heterocycles bearing all-carbon quaternary chiral centers in most of the cases. These results provide not only the efficient synthesis of highly enantioenriched spiro- or polycycles, but also a novel concept in asymmetric catalysis.

References:

[1] You, S.-L. (2016) Asymmetric Dearomatization Reactions, Wiley-VCH.

[2] Tu, H.-F.; Zhang, X.; Zheng, C.; Zhu, M.; You, S.-L. Nature Catal. 2018, 1, 601.

[3] Tu, H.-F.; Yang, P.; Lin, Z.-H.; Zheng, C.; You, S.-L. Nature Chem. 2020, 12, 838.

[4] Jiang, R.; Ding, L.; Zheng, C.; You, S.-L. Science 2021, 371, 380-386..

Contact:

School of Science, Zhuo Peng, Email: pengzhuo@westlake.edu.cn





Time & Date

16:00-17:30, Thursday, June 17th, 2021

Venue

Lecture Hall, 1F, Building 5, Yunqi Campus, Westlake University

Host

Dr. Haihua Lu, PI of School of Science, Westlake University

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research