NEWS & EVENTS Event Calendars Event

Time & Date

3:00-4:30 PM,Tues.,July 20,2021

Venue

Room 312, 3F, Building 3,  Yunqi Campus

Host

Dr. Danyang He, School of Life Sciences

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research

SLS Seminar Series | Wenwen Zeng: Connecting the brain and periphery: Neural control of lipid metabolism and neural-immune response

Time3:00-4:30 PM,Tues.,July 20,2021

Venue: Room 312, 3F, Building 3,  Yunqi Campus

Host:Dr. Danyang He, School of Life Sciences



Speaker:

Dr. Wenwen Zeng

Principal Investigator, Institute for Immunology and School of Medicine, Tsinghua University

Dr.

Dr. Wenwen Zeng received her B.S. degree from Tsinghua University, Beijing. She worked on biochemical reconstitution of RIG-I anti-viral pathway with Dr. Zhijian James Chen at University of Texas Southwestern Medical Center at Dallas during Ph.D. She then joined Genentech Inc. studying Th17 differentiation. She continued postdoctoral training with Dr. Jeffery Friedman at Rockefeller University after moving to New York City and worked on leptin-induced lipolysis, which led to her interest in understanding metabolic homeostasis.  Her group at Tsinghua University now is working on the energy balance and the underlying neural-immune regulation. She was awarded with the Young Investigator Award in 2015, Outstanding Young Scholar Award from Qiu-Shi Science & Technologies Foundation in 2016, Young Investigator Award from Lipid Metabolism and Bioenergetics Subsociety of the Biophysical Society of China in 2018, and the National Science Fund for Excellent Young Scholar in 2018. 


Abstract:

Metabolic activities are regulated by the peripheral nervous system connects the central nervous system with the innervated tissues and organs. The spatial nerve landscape is critical for afferent and efferent signal transmission, and the nerve structure and function are influenced by the peripheral fluctuations. Through establishing the volume fluorescence-imaging technique for adipose tissues, we have visualized the intra-adipose neural network and revealed the dense distribution at the single-fiber resolution on the whole-tissue level. The intra-adipose sympathetic arborizations play crucial roles in regulating the metabolic plasticity of the white adipose tissues, and the nerve density undergoes significant changes in adaptation to the metabolic demands. Meanwhile, we found that neurons could mount intrinsic  immune signaling in response to tissue damage, and the Schwann cells signal to neurons to initiate a neuroinflammatory cascade that transmits the danger signal from the peripheral to the central nervous systems. 


Contact:

Wenyue Yu: yuwenyue@westlake.edu.cn

School of Life Sciences


Time & Date

3:00-4:30 PM,Tues.,July 20,2021

Venue

Room 312, 3F, Building 3,  Yunqi Campus

Host

Dr. Danyang He, School of Life Sciences

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research