NEWS & EVENTS Event Calendars Event

Time & Date

4:00-5:30 PM,Tues., Sep. 14,2021

Venue

Room 312, 3F, Building 3, Yunqi Campus

Host

Dr. Chun-qing Song, School of Life Sciences

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research

SLS Seminar Series | Lingfei Luo:Celluar and Molecular Mechanisms of Brain Vasuclar Regeneration

Time:4:00-5:30 PM,Tues., Sep. 14,2021

地点:西湖大学云栖校区3号楼312会议室

Venue: Room 312, 3F, Building 3, Yunqi Campus

主持人:西湖大学生命科学学院研究员 宋春青

Host:Dr. Chun-qing Song, School of Life Sciences



Speaker:

    Dr. Lingfei Luo

Professor, Southwest University


Abstract:

Damage to regional brain vascular network and neuronal tissues occurs during acute cerebrovascular diseases, such as ischemic stroke. The promotion of vascular regeneration is the most promising therapeutic approach. To understand the cellular and molecular mechanisms underlying brain vascular regeneration, we developed two zebrafish brain vascular injury models using genetic ablation and photochemical thrombosis. Although brain parenchyma is physiologically devoid of lymphatic vasculature, we found that cerebrovascular injuries induce rapid ingrowth of meningeal lymphatics into the injured parenchyma. The ingrown lymphatics on one hand become lumenized to drain interstitial fluid to resolve brain edema, on the other hand act as "growing tracks" for nascent blood vessels. The ingrown lymphatic vessels undergo apoptosis and clearance after cerebrovascular regeneration. This study reveals a pathological function of meningeal lymphatics, through previously unexpected ingrowth into brain parenchyma and a newly identified lymphatic function as vascular "growing tracks".


Contact:

School of Life Sciences

Wenyue Yu: yuwenyue@westlake.edu.cn

Time & Date

4:00-5:30 PM,Tues., Sep. 14,2021

Venue

Room 312, 3F, Building 3, Yunqi Campus

Host

Dr. Chun-qing Song, School of Life Sciences

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research