NEWS & EVENTS Event Calendars Event

Time & Date

16:00-17:30, Thursday, Oct. 14th, 2021

Venue

Meeting Room 311, Building 4, Yunqi Campus, Westlake University

Host

Dr. Li Deng, Xu Yiming Endowed Chair Professor of School of Science, Westlake University

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research

Chemistry Colloquium | Xumu Zhang: Application of Multidentate Chiral Ligands in Highly Efficient Asymmetric Hydrogenation

Time16:00-17:30, Thursday, Oct. 14th, 2021

Host: Dr. Li Deng, Xu Yiming Endowed Chair Professor of School of Science, Westlake University

Venue: Meeting Room 311, Building 4, Yunqi Campus, Westlake University

Prof. Xumu Zhang

Department of Chemistry, Southern University of Science and Technology

E-mail: zhangxm@sustech.edu.cn


Speaker

Xumu Zhang received his BS from Wuhan University (1982) and MS from Fujian Institute of Material Structure, Chinese Academy of Sciences (1985) with Professor Jiaxi Lu and University of California, San Diego (1987) with Professor Gerhard N. Schrauzer. He received his PhD in chemistry in 1992 from Stanford University under the guidance of Professor James P. Collman (The supervisor of Nobel Prize winner Sharpless and Grubbs). He pursued postdoctoral research at Stanford University from 1992 to 1994. Before joining SUSTech in 2015, he was a professor of chemistry in Pennstate University and distinguished professor in Rutgers University. Prof. Zhang is the first person from mainland China, who won the prestigious ACS Cope Scholar Award in 2002 for his invention of the toolbox of chiral ligands and for his development of homogeneous catalysts that make it practical to synthesize many chiral molecules, especially those having biological significance. In 2014, a chemical reaction was named after his name as Zhang Enyne Cycloisomerization. In frontier areas of science, Prof. Zhang has applied over 50 U.S. and international patents, published more than 300 papers and the papers have been cited over 15000 times. His research interests include highly efficient and selective hydrogenation and hydroformylation, biomass conversion and green synthesis of chiral drugs.

Selective Publications

1. Wang, J.; Shao, P.-L.;* Lin, X.; Ma, B.; Wen, J.; Zhang, X.*, Angew. Chem., Int. Ed. 2020, 59, 18166-18171.

2. Duan, Y.-N.; Du, X.; Cui, Z.; Zeng, Y.; Liu, Y.; Yang, T.; Wen, J.;* Zhang, X.,* J. Am. Chem. Soc. 2019, 141, 20424-20433.

3. You, C.; Li, X.; Gong, Q.; Wen, J.;* Zhang, X.,* J. Am. Chem. Soc. 2019, 141, 14560-14564.

4. Tan, X.; Gao, S.; Zeng, W.; Xin, S.; Yin, Q.;* Zhang, X.,* J. Am. Chem. Soc. 2018, 140, 2024-2027.

5. Chen, G.-Q.; Lin, B.-J.; Huang, J.-M.; Zhao, L.-Y.; Chen, Q.-S.; Jia, S.-P.; Yin, Q.;* Zhang, X.,* J. Am. Chem. Soc. 2018, 140, 8064-8068.

6. Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.*; Lu, Y.; Zhang, X.* Nat. Chem. 2021, 13, 692-697.

Abstract:

The highly efficient and selective asymmetric hydrogenation is a key widely used technology for green synthesis of drugs. As early as 1998, Professor Xumu Zhang has already proposed the concept of using tridentate ligands in simple ketone hydrogenation. His group designed and synthesized ambox ligands, which showed excellent enantioselectivity in ruthenium-catalyzed asymmetric transfer hydrogenation. In 2016, Prof. Zhang creatively introduced ferrocene framework into the tridentate ligand and synthesize a novel ligand f-amphox, which showed extremely high activity and enantioselectivity (>1,000,000 TON, 99% ee) in the hydrogenation of simple ketones. On this basis, Prof. Zhang has successively developed a series of chiral tridentate ligands based on ferrocene skeleton, including f-amphol, f-ampha, f-amphamide, Yao-PNP, as well as electron-rich Heng-PNP. These tridentate ligands have been used in the green synthesis of many important drugs, such as ezetimibe and montelukast, which also created remarkable economic benefits. 


Main References:

1. Jiang, Y.; Jiang, Q.; Zhang, X.,* J. Am. Chem. Soc. 1998, 120, 3817-3818.

2. Wu, W.; Liu, S.; Duan, M.; Tan, X.; Chen, C.; Xie, Y.; Lan, Y.;* Dong, X.-Q.;* Zhang, X.,* Org. Lett. 2016, 18, 2938.

3. Wang, J.; Shao, P.-L.;* Lin, X.; Ma, B.; Wen, J.; Zhang, X.,* Angew. Chem., Int. Ed. 2020, 59, 18166.

4. Zeng, L.; Yang, H.; Zhao, M.; Wen, J.;* Tucker, J. H. R.; Zhang, X.* ACS Catal. 2020, 10, 13794.

5. Zhang, F.; Zeng, J.; Gao, M.; Wang, L.; Chen, G.-Q.*; Lu, Y.; Zhang, X.* Nat. Chem. 2021, 13, 692-697.

Contact:

School of Science, Tingting Xu, Email: xutingting@westlake.edu.cn


Time & Date

16:00-17:30, Thursday, Oct. 14th, 2021

Venue

Meeting Room 311, Building 4, Yunqi Campus, Westlake University

Host

Dr. Li Deng, Xu Yiming Endowed Chair Professor of School of Science, Westlake University

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research