NEWS & EVENTS Event Calendars Event

Time & Date

4:00-5:30 PM,Tues., Nov. 23,2021

Venue

Room 312, 3F, Building 3, Yunqi Campus

Host

Dr. Ting Zhou, School of Life Sciences

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research

SLS Seminar Series | Xiaolei Su:Membrane, phase separation and immune signaling

Time:4:00-5:30 PM,Tues., Nov. 23,2021

Venue: Room 312, 3F, Building 3, Yunqi Campus

Host:Dr. Ting Zhou, School of Life Sciences



Speaker:


Dr. Xiaolei Su, Assistant Professor of Cell Biology, Yale School of Medicine


My overarching research goal is to understand signaling pathways mediating immune responses and to leverage this knowledge to the engineering of immune cells for cancer therapy. My current research program focuses on 1) understanding how phase separation regulates immune signaling; 2) reprogramming T cells and granulocytes for cancer therapy.


Abstract:

The overarching research goal of my lab is to understand signaling pathways mediating immune responses and to leverage that knowledge to the engineering of immune cells for cancer therapy. We have established a supported membrane-based system for reconstituting 2D biomolecular condensates in vitro and for imaging cellular membrane receptor dynamics at high spatial and temporal resolutions. Using this system and cell engineering approaches, we aim to address the following questions: 1) How do biomolecular condensates regulate the T cell receptor signaling? 2) How is antigen signal transmitted across the membrane to activate the chimeric antigen receptor (CAR)? Results from these studies guided the design of CAR-Ts for a better targeting of cancer antigens.


Contact:

Wenyue Yu: yuwenyue@westlake.edu.cn

School of Life Sciences


Time & Date

4:00-5:30 PM,Tues., Nov. 23,2021

Venue

Room 312, 3F, Building 3, Yunqi Campus

Host

Dr. Ting Zhou, School of Life Sciences

Audience

Faculty and Staff,Graduate Students,Undergraduate Students

Category

Academics and Research