Time：10:00-11:30 AM，Friday, Jan. 13th，2023

    Host：Dr. Ren Sun, Chair Professor, School of Life Sciences

    Venue：Room 312, Building 3, Yunqi Campus

Speaker:

Ka-Ming Chan, Distinguished professor of the School of Basic Medicine , Zhejiang University

Professor Francis Chan graduated from the University of California, San Diego with Summa Cum Laude, and obtained his PhD in molecular cell biology from the University of California, Berkeley, and then started his  postdoctor training at the National Institutes of Health. He has successively worked as a professor of the University of Massachusetts Medical School, Duke University Medical School, and Vice Chair of the Department of Immunology of Duke University. Professor Chan is currently a distinguished professor of the School of Basic Medicine of Zhejiang University, the Second Affiliated Hospital of Zhejiang University School of Medicine and Liangzhu Laboratory, and a Adjunct professor of the Department of Immunology of Duke University. 

Abstract:

Necroptosis is a pro-inflammatory form of cell death with critical functions in host defense and tissue homeostasis.  The key signal adaptors for necroptosis are marked by a unique protein-protein interaction termed the “RIP homotypic interaction motif” (RHIM).  Emerging evidence indicates that many pathogens encode inhibitors that interfere with the activities of the RHIM adaptors.  In this seminar, we will discuss the molecular mechanism by which the RHIM adaptors regulate necroptosis and strategies employed by viruses to counteract this host defense response.  We will also discuss the cell death-independent functions of the RHIM adaptors in tissue homeostasis.

Contact：

Wenyue Yu: yuwenyue@westlake.edu.cn

School of Life Sciences